A new way of designing antibiotics could support the discovery of new treatments for drug-resistant infections.

Acinetobacter baumannii is a Gram-negative opportunistic pathogen responsible for severe hospital-acquired infections worldwide. Its ability to survive desiccation and adhere to medical devices ...

Efflux pumps in Gram-negative bacteria actively export antibiotics out of the cell, and their overexpression can confer multidrug resistance. Two new studies explore the effect of the overexpression ...

Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the antibiotic bedaquiline was introduced in 2012, it was the first new tuberculosis ...

Monoclonal antibody-based therapies for hematologic malignancies. For cytotoxic agents to have an effect on tumor cells, drugs must first be transported into the cell, potentially be metabolized to an ...

High-density lipoprotein (HDL) may provide cardiovascular protection by promoting reverse cholesterol transport from macrophages. We hypothesized that the capacity of HDL to accept cholesterol from ...

It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux capacity, the ability of ...

Besides their normal role, pump overexpression confers drug resistance. Knowing the structure is a step to disabling the pumps with inhibitors BIRMINGHAM, Ala. – Tuberculosis is the world’s leading ...

New platform empowers organizations and partners worldwide with powerful cloud-based document capture and workflow automation. We look forward to supplying the market with state-of-the-art SaaS ...