F-box proteins have pivotal roles in the development and progression of human malignancies through governing the turnover of key factors that are involved in multiple cellular processes, including ...
F-box proteins are the substrate-targeting subunits of S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin ligase complexes. In mammals, approximately 70 F-box ...