Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

In a landmark achievement in biological imaging, researchers at the University of California, Berkeley and Biohub today announced the successful demonstration of the laser phase plate, a novel device ...

Quantitative phase imaging (QPI) has become a vital tool in bioimaging, offering precise measurements of wavefront distortion and, thus, of key cellular metabolism metrics, such as dry mass and ...

Installed in a custom Titan Krios, the laser phase plate enhances motion correction, early‑frame recovery, and 3D classification and alignment.

Hosts of new applications have turned the light microscope into an exquisitely sensitive measuring device that can be used to image dynamic cellular events right down to the molecular level. Indeed, ...