Researchers have used an experimental mRNA therapy to make old immune cells in mice behave as if they were young again, ...

During vaccination, the immune system is purposefully exposed to weakened, inactivated, or a component of pathogens so that the body can recognize their molecular structures in the future and mount a ...

New research reveals that aging immune cells can become locked in a self-sustaining inflammatory state, worsening the body’s ...

Figure 6. Senescent heterogeneity model based on DNA content. Compared to G1-arrested cells, G2-arrested senescent cells express higher levels of senescence-associated markers, secrete more IL-6, and ...

Researchers identify a decline in NAD levels as a key driver of T cell dysfunction and offer a potential rejuvenation strategy to improve immunotherapy outcomes in older cancer patients CAR-T therapy ...

A team of Duke researchers have developed an artificial intelligence tool that can help identify cells that play a significant role in aging and age-related diseases. The AI-based method, DeepScence, ...

One of the main changes is a loss of the innate immune system's naive T cells, the first line of defense against pathogens, and an increase in the adaptive immune system's memory T cells. This ...

Taken together, these advances suggest that part of age-related immune decline is driven by specific, potentially reversible ...

As people grow older, their immune systems do not simply slow down, they often become locked into a simmering, ...