A schematic showing how R-loops, a hybrid of RNA and DNA, can form during DNA transcription when the messenger RNA chain being assembled by the RNA polymerase binds to one of the DNA strands. R-loops ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 50 (December 13, 2022), pp. 1-12 (12 pages) R-loops, or RNA:DNA hybrids, can induce DNA damage, which ...

“There are currently limited therapeutic options for elderly patients with myeloid malignancies, who are ineligible for stem cell transplantation,” commented Dr. Sayantani Sinha, a postdoctoral ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...